UPFs, or ultra-processed foods—like packaged snacks, sugary drinks, instant meals and fast food—are often renowned for their convenience, low cost and pleasant taste, but they could be taking a major toll on our health, even more than we once thought. Today, I am sharing an interesting study I came across, supported by the Intramural Research Program of the National Institutes of Health, National Institute of Diabetes & Digestive & Kidney Diseases, which demonstrated the negative effects of UPFs on our health.
I was particularly intrigued when this nutrition-based RCT (randomized controlled trial) surfaced within the current discussion around UPFs. Nutrition research is rarely conducted as an RCT, resulting in a mountain of conflicting observational studies where associations between variables are identified but causation cannot be drawn. The lack of RCT makes nutrition research particularly confusing and is often compounded by publication bias, media interpretation, reductionist thinking and self-interest. Note that the generalizability of this study is limited due to the lack of consumer choice and the in-patient nature of the study design. Further, the sample size was small, the time in each study group was short and a washout period between groups was absent. But the implications remain interesting and something to consider when we make choices about what we’re consuming. (Keep in mind, this study is from 2019, so its discussion around UPFs precedes the current political climate.) Let’s take a close look at this study and the findings: THE VARIABLES: The study examined 20 weight-stable participants: 10 males and 10 females aged 18-50, all who were admitted to the NIH Clinical Center for a continuous 28-day period. For a two-week period, participants were randomly assigned a UPF diet (as defined by NOVA) or an unprocessed diet. After two weeks, without a washout period, they switched diets. All 20 participants completed the study. Each participant was provided with three meals a day. The weekly per-person costs of these diets were estimated to be $106 for the UPF diet and $151 for the unprocessed diet. The foods presented among the two diet groups were matched for calories from sugar, fat, sodium, fiber and macronutrients. Participants were instructed to eat as much as they wanted within a one-hour window for each meal. Snacks were also made available for each diet group. MEASURING THE VARIABLES: Participants wore continuous glucose monitors (CGMs) to track glucose, accelerometers to track energy expenditure (calculated as METs), and spent one day a week in a respiratory chamber to track energy components. Fasting blood was drawn at baseline and on the final days in each diet group. Participants also responded to surveys assessing appetites, sensory experience and palatability. To offset deconditioning from sedentary behavior, participants performed three, 20-minute cycle sessions at a controlled intensity. THE OUTCOMES: While on the UPF diet, participants consumed 500 more daily calories per day than when on the unprocessed diet, which correlated with an increase in calories consumed per minute in the UPF diet group. The extra calories consumed were from carbohydrates and fat (notably, not from protein). Not surprisingly, participants showed increases in weight and body fat mass when on the UPF diet and reductions in weight and body fat mass when on the unprocessed diet. While on the UPF diet, fat oxidation was reduced, while insulin secretion and blood glucose increased. While on the unprocessed diet, appetite-suppressing hormone PYY levels increased, along with free fatty acids and free T4, while hunger hormone ghrelin, adiponectin, total cholesterol, hsCRP and Total T3 levels decreased. UPFs AND BRAIN HEALTH Last month, in Concierge Choice Physicians members’ only wellness program, Motivated Mondays, CCP closely examined the role of UPFs on cognitive health. UPFs have been associated with a number of health concerns, including cardiovascular disease, diabetes, and mental health disorders. In this study, a well-controlled RCT, we see it corresponding in a linear, stepwise fashion with weight gain via increased calorie consumption. In addition, even in the short term, the biomarkers hint at the potential for additional inflammatory and metabolic health concerns. WHAT ALL OF THIS MEANS FOR US: With all this in mind, strongly I encourage you to eat and identify real, unprocessed food. To help, you can ask yourself the following three questions we should ask ourselves before adding a food item to our grocery baskets:
If your answer is no to any of the above questions, try to avoid it. As your concierge physician, I am always available to you, especially when it comes to helping you make healthier choices. Feel free to reach out with your individual questions.
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As our loved ones age, the reality of their evolving needs comes into view and that may include playing an advanced role in their care. You may already know from personal experience that family caregivers are essential contributors to the healthcare system. In fact, it is estimated that 1 in 5 adults in the U.S. provide unpaid care to a family member or friend, many of whom are given little to no advanced notice. In order to help manage stress, expectations and provide the best care possible, you can anticipate the call to care by considering the following tips, resources and self-care advice.
Becoming A Caregiver Patience is often the most important—and toughest—practice in caregiving. Keep in mind your loved one’s emotional needs and focus on/promote their dignity and independence as much as possible. Be an active listener and be attentive to your loved one’s verbal and non-verbal cues. Researching their diagnoses and speaking with their doctors (when appropriate) about their condition can help you to better understand what is needed from you in the management of their care. Assess what is needed in terms of time management and organizational needs, including coordinating doctor’s office visits and household maintenance. If your loved one has more than one caregiver, define the roles of each contributing person, keeping in mind distance, time, resources and skills/experience. This can help you prioritize and anticipate the management of certain items and avoid future conflicts. Document everything, including your loved one’s routines, diagnoses, medications, healthcare professional care team, emergency contacts and other important phone numbers, and upcoming appointments. You may consider keeping a care journal to organize these items. In addition, it will be important to organize medical records and legal documents (such as power of attorney documents, medical directives and wills) in one place. Among the approximately 53 million Americans in caregiving roles, 70% offer unpaid elder care assisting adults aged 65 and older. However, in certain circumstances, one can be paid to provide caregiving to a family member. Adult daycares and home healthcare programs may be available to support the person you are caring for. Medicare, Medicaid, veterans' benefits or private health insurance may pay for a portion or all of the costs depending on income, degree of disability and other factors. You may also be able to enroll the person you’re caring for in long-term care insurance, which covers the costs of care for individuals who are no longer able to care for themselves and/or have cognitive impairments. Long-term care options may include home care, assisted living, skilled nursing care facilities or residential facilities. Consult with your loved one’s insurance agent to determine if they qualify for long-term care insurance. For end-of-life care, hospice is excellent at providing durable medical equipment (DME) and nursing (in some instances, care time may be limited). Patients usually incur little-to-no out-of-pocket costs for Hospice care, but insurance coverage varies across networks and among individuals, so be sure to research costs. Organizing Yours and Your Loved One’s Affairs Ahead of Time It is not uncommon to find your loved one’s affairs in disarray or organized in a fashion that is only meaningful to them. You can get ahead of the entanglement of affairs with Advance Care Planning. The National Institute on Aging has an excellent resource to aid in advance care planning, with checklists and information to help you get organized before caregiving becomes necessary. I also addressed advance care planning in greater depth in my June 2023 blog, which you can find in my blog archives. An often-overlooked consideration for caregivers is access to password-protected devices and social media accounts. If you do not secure those early on, you may need a court order to access them in the future. Apple devices allow a legacy contact designation. And if you anticipate becoming a loved one’s Power of Attorney, research or speak with an attorney about the laws in your state regarding Power of Attorney designations. Taking Care of Yourself As with the oxygen masks on an airplane, we must prioritize our own wellbeing in order to properly care for others. Studies show the degree of a caregiver’s psychological, emotional and physical stress varies by gender and age, with women and caregivers 50 and under experiencing greater stress. Depending on your personal circumstances (like distance from the person you’re caring for, your employment and finances, for example) as well as the severity of disease or disability of the person you are providing care for, caregiving can take many forms and have varying impacts. Being prepared and staying organized can help you to manage the stressors you may encounter. In addition to the usual self-care advice to sleep, move, eat right and keep your doctors’ appointments (be sure to schedule your exam with me each year and contact me for any other health concerns that arise!), decide what you need for yourself to keep going. Whether it’s a daily walk, a phone call with a friend or a coffee date with friends, try to schedule time for yourself each day. Planning that “me time” into your schedule will help you to actually take the time for yourself, and it may help to reduce any associated guilt you may otherwise experience. Moreover, friends and family members may offer you help. While, for many, your first inclination may be to say, “No, thank you,” I would implore you to consider a genuine offer of help. Accepting help with remedial tasks that take up time and energy (like driving to doctor’s appointments, picking up prescriptions, cooking hot meals, walking the dog, etc.) could help to ease your mental or physical burden. Looking for outside support to help you cope with a loved one’s new diagnosis and/or your new role as their caregiver? Take this quiz to discover the endless free and fee-based resources available, ranging from mental health professionals, group therapy sessions, faith leaders and senior centers, to the VA or AARP. And, of course, feel free to contact me with any questions or concerns about your own health and wellbeing. Becoming a caregiver can be incredibly rewarding yet exhausting. To manage your stress, it can be helpful to focus on the tasks at hand, taking it one day at a time, and determining the best way to break down priorities with a special focus on your loved one’s safety, health and emotional needs, as well as your own. Each year, we spring forward into Daylight Saving Time (DST) the second Sunday in March and we fall back to Standard Time the first Sunday in November. The intention of the extra hour of daylight is to conserve energy, but it has a number of adverse health effects.
Beyond a sleep deprived society losing yet another hour of sleep when we spring forward, what is the reason DST is so disruptive to our internal clocks? In essence, every cell in your body has an internal clock that controls your biology on a 24-hour schedule. This is known as the circadian rhythm (CR). The primary driver of the CR is our exposure to lightness and darkness. For optimal functioning, our CR requires exposure to bright light during the day, which keeps us alert and gives us energy during the day, and reduced amounts of light in the evening, which induces drowsiness to get a good night’s rest. However, the opposite happens after DST when it is darker in the morning and lighter in the evening. Your body’s natural CR becomes mismatched with the clock. A misaligned CR will leave you groggy in the morning hours and alert before bed, much like jet lag if you travel west to east. A misaligned CR will not only interfere with your sleep patterns, but also disrupt the appropriate timing of the release of hormones which impact hunger/satiety, mood, immunity, and metabolism. Many agree we should skip the bi-annual time change, and just change the clocks once per year. There are several national petitions circulating to stop “falling back” but most scientists agree eliminating “spring forward” would make more sense, because Standard Time is more closely aligned with our CR. As of now, no changes have been made so we will be switching to DST next weekend, so how can we prepare for Daylight Saving Time?
With these tips and tools, you can adjust your circadian rhythm and conquer the fog and grog of Daylight Savings. With Thanksgiving approaching, my heart is filled with immense gratitude and warmth. I want to take a moment to express just how thankful I am for each and every one of my concierge members. Your decision to join my concierge program and prioritize your health is something I deeply appreciate.
In an era where healthcare often feels like a series of rushed appointments and impersonal interactions, I knew I needed to forge a new approach to patient support and enhance the service my team and I provide. My concierge program became the solution, helping us to build a more personalized patient environment, fostering a mutual dedication to improving health outcomes. This journey has been incredibly rewarding for me, not just as a physician, but as a partner in your health. I’ve seen firsthand the positive changes and improvements that come from a more engaged and proactive approach to healthcare. It’s been inspiring to witness your progress and to work with you to maintain and improve your health over time, with greater continuity and understanding. Together, we are not just managing health. We are thriving. The opportunity to make a real difference in people’s lives is truly fulfilling, and I thank you for making that possible. Practicing Gratitude for Your Health “The heart that gives thanks is a happy one, for we cannot feel thankful and unhappy at the same time.” -Douglas Wood In the spirit of Thanksgiving, I encourage you to identify all that you are thankful for and to develop a regular practice of gratitude. Gratitude is like a personal trainer for your mindset—just a few reps a day can boost your mood and strengthen your outlook! Your practice doesn’t have to be hokey or complicated. It can be as simple as writing one line in a journal each day or keeping a note in your phone to share something that happened that day for which you are grateful. For example, you can start by writing a note that states, “Good things always happen to me.” Then, throughout the day, look for positive things that occur and write them down. When we regularly acknowledge and appreciate the positive aspects of our lives, we shift our focus away from stress and negativity, which can help lower levels of the stress hormone, cortisol. This shift not only improves emotional resilience but also supports better mental health by reducing symptoms of depression and anxiety. Furthermore, gratitude can enhance physical health by encouraging healthier lifestyle choices, such as improved sleep quality and more consistent exercise, which contribute to a stronger immune system and better cardiovascular health. A Final Note Thank you once again for reminding me why I chose this profession, and for being a major contributor to my gratitude practice each day. As we move forward, I remain dedicated to ensuring your membership exceeds your expectations. Your feedback and experiences are invaluable, and I encourage you to share them with me and my team so that we can continue to improve and adapt to better serve your needs. I wish you and your loved ones a wonderful Thanksgiving. As the primary fat in the Mediterranean Diet, olive oil has been studied extensively for its health-promoting benefits. Regular consumption, defined as 1.5 - 4 tablespoons a day, has been observed to reduce the risk of total and cause-specific mortality. But not all olive oils are created the same. Thus, a study comparing the health benefits of EVOO to OO recently caught my eye.
Extra virgin olive oil (EVOO) is distinguished from olive oil (OO) by the extraction process. OO is produced via chemical extraction and processing, whereas EVOO is produced by crushing the olive thereby retaining and preserving the phenol content of the fruit (yes, olives are classified as a fruit!). It is the phenol content of the EVOO which is thought to impart the health-promoting benefits, not the fatty acid content (aka MUFAs). The study participants In the study comparing the two, 12,161 participants were assessed for variables such as sociodemographic factors, self-reported health conditions and medications, and diet, specifically their adherence to the Mediterranean Diet and type of olive oil consumed each day. Participants were followed for a mean 10.7 years. The findings Researchers found the risk of all-cause mortality and cardiovascular mortality was lower in those with the highest reported daily EVOO consumption, and this association was not replicated in those reporting OO consumption. When total daily olive oil consumption was combined (i.e. adding together both OO and EVOO consumption), the risk of mortality was also reduced—but not as low for those with higher daily EVOO consumption (not combined with OO). Interestingly, deeper reductions in all-cause mortality were noted in those reporting both higher EVOO consumption and physical activity, indicating a synergistic effect between the two, the mechanism of action for which is not fully understood. How do we interpret this study? We can start by noting it is not a randomized clinical trial (RCT). Instead, this study is strictly observational, meaning we can observe the results, but we cannot draw conclusions. Had the researchers randomly assigned half the participants to EVOO consumption and half to OO, we would have more conclusive results. So, I dug a little more into the research in PubMed. A review article of 34 studies in which EVOO was compared to other fats found EVOO superior in a variety of biomarkers and health outcomes—this was again believed to be imparted by the phenol content. Where does this leave us? It would seem that EVOO might have benefits above and beyond that of other fats, including plain old olive oil. Specifically, a serving of 2 tablespoons of EVOO a day appears to be beneficial. It’s important to also remember the statistically observed synergy between EVOO and physical activity—so keep moving! Buying EVOO When purchasing, remember to read the label to make sure it says EXTRA VIRGIN olive oil and if you can find it unfiltered that’s even better! Check the expiration date, as phenol content wanes with time. Pesticide residue studies of European olive oils do not indicate contamination above threshold levels, thus if purchasing European olive oils, it may not be important to choose an organic version. And be sure to keep your EVOO away from heat (not next to or above the stove or oven) and away from light. There exists both controversy and contradictory research results regarding the degradation of phenols with cooking. It seems prudent to save the pricey EVOO variety for salad dressings and for finishing/topping soups and vegetables for flavor and mouthfeel. If you have questions about your specific EVOO recommendations in relation to your personal health, please reach out for a chat. You may also feel free to share this blog with your friends and family. SOURCES: Ambra R, Lucchetti S, Pastore G. A Review of the Effects of Olive Oil-Cooking on Phenolic Compounds. Molecules. 2022 Jan 20;27(3):661. doi: 10.3390/molecules27030661. PMID: 35163926; PMCID: PMC8838846. Donat-Vargas, C., Lopez-Garcia, E., Banegas, J.R. et al. Only virgin type of olive oil consumption reduces the risk of mortality. Results from a Mediterranean population-based cohort. Eur J Clin Nutr 77, 226–234 (2023). https://doi.org/10.1038/s41430-022-01221-3 Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Fitó M, Gea A, Hernán MA, Martínez-González MA; PREDIMED Study Investigators. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. 2018 Jun 21;378(25):e34. doi: 10.1056/NEJMoa1800389. Epub 2018 Jun 13. PMID: 29897866. Flynn MM, Tierney A, Itsiopoulos C. Is Extra Virgin Olive Oil the Critical Ingredient Driving the Health Benefits of a Mediterranean Diet? A Narrative Review. Nutrients. 2023 Jun 27;15(13):2916. doi: 10.3390/nu15132916. PMID: 37447242; PMCID: PMC10346407. Gaforio JJ, Visioli F, Alarcón-de-la-Lastra C, Castañer O, Delgado-Rodríguez M, Fitó M, Hernández AF, Huertas JR, Martínez-González MA, Menendez JA, Osada J, Papadaki A, Parrón T, Pereira JE, Rosillo MA, Sánchez-Quesada C, Schwingshackl L, Toledo E, Tsatsakis AM. Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018. Nutrients. 2019 Sep 1;11(9):2039. doi: 10.3390/nu11092039. PMID: 31480506; PMCID: PMC6770785. Guasch-Ferré M, Li Y, Willett WC, Sun Q, Sampson L, Salas-Salvadó J, Martínez-González MA, Stampfer MJ, Hu FB. Consumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults. J Am Coll Cardiol. 2022 Jan 18;79(2):101-112. doi: 10.1016/j.jacc.2021.10.041. PMID: 35027106; PMCID: PMC8851878. Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A. Olive oil, the Mediterranean die t, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr. 2004 Oct;80(4):1012-8. doi: 10.1093/ajcn/80.4.1012. Erratum in: Am J Clin Nutr. 2005 May;81(5):1181. PMID: 15447913. A Scary Look at Data Misrepresentation in Nutritional Science
As consumers of information, we are barraged daily with conflicting information, nowhere is this more evident than in nutrition research where the information seems to change from week to week. Why is this the case? We can start with how people eat: are the people in the fake headline above just eating ice cream? Likely they are eating the usual ice cream companions like cones, sprinkles, whipped cream and hot fudge. People follow patterns of eating behavior. It is virtually impossible to take a reductionist view of what people eat and limit it to a single food or nutrient. Then, we can look at how the data is collected. Most often, nutrition research asks people to recall what they ate over a given period of time in the past. Do you recall how much ice cream you ate last summer? Last month? Last week? Was it soft serve or hard? What flavor was it? Was it dairy or dairy-free? Did you add toppings? Was it served in a cup or a cone? What type of cone? …Just how accurate do you think the information collected is? Next, we can examine the participants in the study. How many participants are needed before one can make the observation in our fake headline? 3? 30? 300? What were the demographics of the participants? Was it a diverse group of people (age, ethnicity, socioeconomic status, geographical location, etc.)? If all the participants in our fake headline were 80-year-old Caucasian females living in the Bronx, then it would be nonsensical to the extrapolate trends from this data to anyone other than 80-year-old Caucasian females living in the Bronx. Then, ask yourself, is observation causation? The answer is no. That is a fundamental issue with study design. Much nutrition research is observational. We observe “associations” between variables, but we cannot control unforeseen variables. Let’s take our fake headline: What if the participants in the study ate their ice cream on a sugar cone? How do we know the shark bite wasn't due to the cone and not the ice cream at all? By not measuring the sugar cone as a variable we have made a false association between ice cream and shark attacks. In addition, it is rare in nutrition research to see a “gold standard” randomized control trial (RCT) in nutrition whereby people are randomly assigned to an intervention and a control group. In our fake headline, one group would eat ice cream, one group would not (the control group) but they would both go swimming at the beach. Then we would be able to draw comparisons between the two groups about a shark attack. Sometimes the research comes up flat and nothing of interest is found. These negative results are important! They add to the body of knowledge on a subject. However, negative results aren’t highly sought after and are rarely published. This is referred to as publication bias. What if 10 previous studies found no association between eating ice cream and shark attacks, but because this was a positive result it was the only one published? The body of knowledge suffers as does the information disseminated to the public. It is sad but true, that much research is funded by industries. The nut industry funds much of the research on nuts. The cacao industry funds much of the research on chocolate, and so on. Again, positive findings are more likely to be published, negative findings are repressed. Unfortunately, these positive findings are then used by the government to make nutrition guidelines and recommendations. Researchers are human, they have egos and pride. The careers of scientists are built on their hypotheses, and, like industries, they have a vested interest in positive findings. Disappointingly, research is replete with insidious behavior meant to protect and promote careers. Finally, there is the media; their job is to promote ratings. They are not obligated to properly vet the research (study design, participants, funding, etc.). Additionally, the media fails to properly explain the implication behind the headline (i.e. what does this mean to you?) Where does this leave us, the consumers of information who want to make smart nutrition choices? Do we throw the baby out with the bathwater? Throw our hands up and eat Oreos for breakfast? Pringles for lunch? Not exactly. However, we do have a responsibility to take a look behind the headlines before making dietary decisions that impact our health. Sometimes that may mean getting the original research and using the above to decide if the study is valid for us. Feel free to email Concierge Choice Physicians ([email protected]) with your questions or even send a headline or study to us, and we will be happy to answer your questions. After a few years of a very uncertain travel market, many of us are resuming regular travel and taking much needed vacations. But before you hit the roads and skies for travel, be sure to prepare yourself and pack your bags for medical scenarios.
Importantly, make sure to refill all your prescriptions ahead of your trip at least one week in advance of your departure and always bring at least a few extra days’ worth of medication with you. With the state of the travel industry, there is a high probability of your return not going quite as planned. You should always pack your medications in your carry-on—not in your checked suitcase—just in case your luggage is lost. The Pack Smart Guide from the CDC offers a checklist to help you prepare for a healthy trip, including prescriptions, medical supplies, over-the-counter medicines, supplies to prevent illness or injury, first-aid kits and important documents. Many items in this list would be especially helpful if you are heading off the grid or traveling to an exotic location where medical supplies are not conveniently available at a local drugstore. Also, keep in mind, I do not offer travel vaccines and would need to refer you to a travel health specialist or local pharmacy, so, please plan ahead. The CDC offers a complete list of destinations with travel health notices, recommended vaccines and precautions to consider for your specific destination. Finally, make sure to enter my concierge contact details into your phone—including my cell number and email—and remember to pack your membership card so that you can reach me with any medical concerns during your trip. I can potentially offer a telemedicine visit, call in a prescription or, based on your destination, help to arrange a visit with a local Concierge Choice Physicians provider if needed. As always, feel free to reach me with any questions. Safe travels! Three years ago, we were met with a global health crisis that resulted in many of us putting our other health concerns on pause, and I want to be sure you have all shifted your focus back to your overall health and wellness.
Have you kept up with your yearly physical? Is it time to do a full review of your medicine and treatment regimens? Have you gained or lost significant weight? How are your stress levels, sleep patterns, fitness programs and anxiety? Your annual comprehensive examination could be the foundation of your good health. Diseases and conditions such as hypertension, cancer, and anemia can be asymptomatic, for example, but a thorough history, physical examination, laboratory testing, and an in-depth discussion may prove revealing and lifesaving. We can also take advantage of this time together to create a plan to help you meet your wellness goals. Let’s partner toward your best health. Please contact our office to schedule your annual exam. And as always, I am available should you have any concerns or questions. |
AuthorWernher Ovalle, MD is a primary care specialist at Newport Beach Internal Medicine Archives
June 2025
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